Infeksi Dengue Sekunder: Patofisiologi, Diagnosis, dan Implikasi Klinis
DOI:
https://doi.org/10.55175/cdk.v50i2.518Keywords:
Dengue sekunder, DHF, diagnosis, implikasi medis, patofisiologiAbstract
Infeksi dengue sekunder merupakan infeksi dengue yang terjadi kali kedua. Infeksi kedua dengan serotipe berbeda dapat menyebabkan
penyakit dengue yang lebih berat. Penelitian menunjukkan bahwa 98% kasus dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) merupakan infeksi dengue sekunder. Patofisiologi yang menjadikan infeksi dengue sekunder lebih berat belum sepenuhnya dipahami, diduga berkaitan dengan mekanisme antibody dependent enhancement (ADE). Membedakan infeksi dengue primer dan sekunder penting agar dokter dan tenaga kesehatan mampu memprediksi prognosis dan keluaran klinis pasien.
Dengue secondary infection is the second dengue infection. A second infection with different serotype tend to be more severe. Data shown that 98% cases of dengue hemorrhagic fever/ dengue shock syndrome (DHF/DSS) are dengue secondary infection. The pathophysiology of more severe cases is not fully understood; it is suspected to be related to antibody dependent enhancement (ADE) mechanism. Differentiating primary and secondary dengue infection is important to predict patient’s prognosis and clinical outcome
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